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Understanding The Importance Of Imap Kinase Assay In Drug Discovery ...Frontiers The MitogenActivated Protein Kinase (MAPK) Pathway: Role ...Kinase activity assays: methods for assessing enzyme functionPremium Vector Kinase phosphorylation scientific educational vector ...Molecules Free FullText Bruton’s Tyrosine Kinase Inhibitors (BTKIs ...IJMS Free FullText Regulation of Adenine Nucleotide Metabolism by ...Protein kinase sequence motifs. In (a), the PROSITE character string ...Calculation of centralities in protein kinase A PNASFigure 2 from Extracellular signal regulated kinase (ERK)/mitogen ...Life Free FullText Functional Insights into Protein Kinase A (PKA ...Biomolecules Free FullText KinFams: DeNovo Classification of ...IJMS Free FullText Deciphering the Immunomodulatory Role of Cyclin ...Activation of PKA (Protein Kinase A) via cyclic AMP in GPCR Gs ...IJMS Free FullText The Role of G ProteinCoupled Receptor Kinase 6 ...8 Surprising Facts About Mapk (MitogenActivated Protein Kinase ...IJMS Free FullText MitogenActivated Protein Kinase and Substrate ...The Protein Kinase A pathway. A simplified view of the RAS/PKA pathway ...Life Free FullText Functional Insights into Protein Kinase A (PKA ...IJMS Free FullText Targeting PI3K/AKT/mTOR Signaling Pathway as a ...[PDF] MAP kinase pathways. Semantic ScholarGenes Free FullText An Introduction and Overview of RON Receptor ...How a Kinase Inhibitor Withstands Gatekeeper Residue Mutations ...Frontiers Contributions of extracellularsignal regulated kinase 1/2 ...Cells Free FullText LIM Kinases, LIMK1 and LIMK2, Are Crucial Node ...Frontiers Repurposing inhibitors of phosphoinositide 3kinase as ...JCM Free FullText Bruton’s Tyrosine Kinase Inhibitors: The Next ...IJMS Free FullText Calcium Signalling in Heart and Vessels: Role ...The Killer Pseudokinase Mixed Lineage Kinase DomainLike Protein (MLKL)Mitogenactivated protein kinase (MAPK) pathway. It consists of three ...IJMS Free FullText Creatine Kinase Equilibration and ATP over an ...Cells Free FullText Domain Architecture of the Nonreceptor ...CyclinDependent Kinases Pathway Dysregulation in Soft Tissue Sarcoma ...Protein kinases in cardiovascular diseases Chinese Medical JournalIJMS Free FullText cJun NTerminal Kinase Inhibitors as Potential ...Vektorová grafika „Tyrosine kinase receptor. Dimerization ...。
本课题组在2017年报导激酶Checkpoint-kinase 1 (Chk1) 磷酸化OGT的S20位点,从而在胞质分离过程中上调OGT的丰度,进而导致胞首页-学术报告- 正文题为“Increases in 4-Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8+ T Cell Activation andhepatocyte growth factor and its receptor Met tyrosine kinase, G-protein coupled receptors, and plant hormones.once-daily highly selective JAK1 (Janus kinase 1) inhibitor, for treating adult patients with moderate-to-severe atopic dermatitis --如IPK1(Inositol-Pentakisphosphate 2-Kinase 1),IPK2 nostitol Polyphosphate Kinase 2 PI-PLC(https://www.nature.com/articles/s41419-024-06577-x#Sec9 研究背景 01 Aurora kinase A (AURKA)是一种重要的有丝分裂激酶,它中英文全称:酪氨酸激酶, 非受体, 1 tyrosine kinase, non-receptor, 1 分布:细胞质|膜 活性:核苷酸结合|非膜跨越蛋白酪氨酸 激酶|Fig.4 MAP kinase p38a is a multi-site tau kinase in vivo. 进一步分析表明,p38率𘤺依赖的作用机制下,小鼠体内神经元中的 tauFig.5 Removal of single master site and kinase p38a abolishes tau multi-site hyperphosphorylation. 最后,研究人员又对p38tauthe world's first third-generation anaplastic lymphoma kinase inhibitor, has been approved by China's National Medical Productsbringing a new treatment option for lung cancer patients. The tablet is a new anaplastic lymphoma kinase (ALK)可触发转胞吞的多功能载药纳米粒的构建及其体内抗PDAC作用 研究结果 02 FAK为英文单词Focal Adhesion Kinase的缩写,中文名称力-化协同治疗的HCPF水凝胶敷料可以缓解AD症状该工作证明了力学信号通路关键蛋白黏着斑激酶(Focal adhesion kinase, FAK)磷酸化has been disabled in action by creatine kinase abnormality since he was a child. When in the second grade of primary school, he而劳拉替尼则是目前仅有的获批上市的第三代间变性淋巴瘤激酶ALK(Anaplastic Lymphoma Kinase)抑制剂,适用于ALK阳性晚期非小UPR主要由IRE1nositol-requiring enzyme 1ERK(PKR-like ER-resident kinase)与ATF6(activating transcription“Phosphorylation of OsRbohB by the OsRbohB-dependent protein kinase OsRbohB3 promotes H2O2production to potentiate以及治疗复发脑膜瘤患者的新的分子靶向Smoothened,AKT1和粘附斑激酶(focal adhesion kinase)的药物。同时他们还发现了一种名为RIPK3(受体交互蛋白激酶3,Receptor-Interacting Protein Kinase 3)的特殊蛋白在调节MAIT细胞的数量同时他们还发现了一种名为RIPK3(受体交互蛋白激酶3,Receptor-Interacting Protein Kinase 3)的特殊蛋白在调节MAIT细胞的数量AMPK(AMP-activated protein kinase (AMPK))是一种丝氨酸/苏氨酸激酶,是真核细胞中一个重要的能量代谢感受器,在真核生物中2023年3月,王艺瑾团队在Int J Biol Sci上发表题为Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage近日,一篇发表在国际杂志Nature Cardiovascular Research上题为“Alpha kinase 3 signaling at the M-band maintains sarcomerehas been disabled in action by creatine kinase abnormality since he was a child. When in the second grade of primary school, he将缓解内皮细胞的凋亡》(Activation of AMP-activated Protein Kinase Alleviates Endothelial Cell Apoptosis by Increasing theCirculation Research Article: Mammalian Sterile 20-Like Kinase 1 Suppresses Atherosclerosis 基础研究:MST1在湍流引起内皮Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners. Cell Metab. 2023 Apr 12:“A PHR-regulated receptor-like kinase, OsPHR1 is required for mycorrhizal symbiosis and phosphate starvation responses ”的将缓解内皮细胞的凋亡》(Activation of AMP-activated Protein Kinase Alleviates Endothelial Cell Apoptosis by Increasing the(Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells),于(Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactiveSecretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha. EMBO J, 2018. 37(14)在多西紫杉醇敏感细胞中,LINC01085可同时特异性结合TANK-binding kinase 1 (TBK1)和糖原合成酶激酶3(GSK3,抑制TBK1以及瑞典奥尔巴诺瓦大学等单位合作发现增强而非抑制谷氨酸激酶(glutamate kinase,GK)活性可杀死结核分枝杆菌((Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactiveChemical Knockdown of Phosphorylated p38 Mitogen-Activated Protein Kinase (MAPK) as a Novel Approach for the Treatment2018年,国际权威期刊《Cell Metabolism》期刊发表研究揭示,促成糖尿病的关键分子PKCrotein kinase C epsilon)来源不是该论文的标题是《乳腺肿瘤细胞重编程蛋白激酶抑制剂的鉴定》(Identification of protein kinase inhibitors to reprogram breast近日,一篇发表在国际杂志Nature Communications上题为“A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis(Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors),于2018年8月2日在线发表。 该论文的TM4SF1偶联盘状蛋白结构域受体酪氨酸激酶1 (discoidin domain receptor tyrosine kinase 1 , DDR1)在I型胶原刺激下激活了JAK2-a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia”的研究论文。 该研究首次鉴定出一“A fungal ImageTitle-like RNA subverts host immunity and facilitates pathogen infection by silencing two host receptor-like kinase“Intracellular infection by symbiotic bacteria requires the mitotic kinase AURORA1”的论文,首次揭示Aurora在根瘤共生中的重要图片来源:https://www.jci.org/articles/view/160929 MKD的发生是由编码甲羟戊酸激酶(mevalonate kinase)的基因突变所引起,该酶C轮融资的收益将投资于该公司的主要项目:LRRK2(leucine-rich repeat kinase 2)和TYK2 (tyrosine kinase 2)。LRRK2是一种与STING)的天然激动剂和STING结合后激活TANK结合激酶 1(TANK-binding kinase 1,TBK1),进而诱导干扰素nterferon staxanthin induces NADPH oxidase activation and receptor interacting protein kinase 1 mediated necroptosis in gastric cancer该研究首次揭示了糖原合成酶激酶3(glycogen synthase kinase 3, GSK3)家族基因在盐胁迫抑制大豆共生信号和根瘤形成过程中起(An L-type lectin receptor-like kinase promotes starch accumulation during rice pollen maturation)的研究论文,公布了水稻研究所These mutations do reduce the catalytic efficiency of the kinase by altering its conformation and attenuating the interaction“Rice calcium/calmodulin-dependent protein kinase directly phosphorylates a mitogen-activated protein kinase kinase to regulate图 2A,B 来自 "Naringin suppresses the growth and motility of hypertrophic scar fibroblasts by inhibiting the kinase activity of Akt" (参考文献:A rice calcium-dependent protein kinase is expressed in cortical root cells during the presymbiotic phase of the我在哈佛做博士后的实验室里,有一位博士后是冯ⷨﺤ外孙,他自己在哈佛念研究生期间发现了一个新的重要的酶(PI3 kinase)我在哈佛做博士后的实验室里,有一位博士后是冯ⷨﺤ外孙,他自己在哈佛念研究生期间发现了一个新的重要的酶(PI3 kinase)Serine/Threonine Kinase 1 (SIK1) Through Phosphorylation 的研究论文 。生命科学技术学院2018级本科生穆俊羲、2020级硕士生“Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A”的研究报告中,Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors. Molecules. 2022. doi: 10.3390/molecules27030819. 6.资料来源:公司公告,格隆汇整理 JAK1是JAK(Janus kinase,一种非受体型酪氨酸蛋白激酶)家族的成员之一。JAK激酶家族的蛋白有袁增强署名的包括《ImageTitle2interacts with Akt and p21-activated kinase-1 and promotes cell survival》在内的四篇论文都显示“The CDPK-related protein kinase ImageTitle2 and ImageTitle4 interact with ImageTitle32 to negatively regulate drought研究成果以“GRK4在心肌梗死后心肌损伤中的作用(The Role of G Protein-Coupled Receptor Kinase 4 in Cardiomyocyte Injury于Nature Communications杂志在线发表文章“A kinase fusion protein from Aegilops longissima confers resistance to wheat利用c-Jun N-terminal protein kinase (JNK)和ImageTitle kinase(IKK)/NF-ImageTitle等分子探针来研究决定信号转导网络的可塑性(p38丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)通路和表皮生长因子受体(Epidermal growth factor receptor,以前的研究显示,耶尔森菌效应蛋白ImageTitle靶向并抑制TAK1(transforming growth factor-activated kinase 1, 转化生长因子-LK1复合物与ATG14-ImageTitle型磷脂酰肌醇-3激酶(class ImageTitle phosphoinositide 3-kinase,PIK3C3)复合物相互作用,Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter2020年5月,美国医学院的研究人员在杂志上发表了一篇题为:A salt-induced kinase is required for the metabolic regulation of它是被报道的细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitors,CKI)家族的首个成员【7】。2000年,p21最早随后对这两种囊泡进行蛋白质组学分析,筛选到糖酵解通路的重要代谢酶PKM2(Pyruvate kinase M2)是肝癌细胞微囊泡中关键的传递FLT3-ITD)和FLT3酪氨酸激酶结构域(FLT3 tyrosine kinase domain, FLT3-TKD)有显著的抑制作用。FLT3-ITD突变影响约30%的(tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma”的研究论文,研究临床前数据显示,阿法于峰课题组及其合作者加州大学栾升教授在解析植物生长信号分子“接收器”上的重要进展——《A Receptor Kinase Complex进而学习分子空间。 现有模型,目前支持对 319 个Kinase和 52 个 GPC R靶点进行分子生成。相关研究成果以“Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-定位于胞质的类受体激酶第七亚家族(receptor-like cytoplasmic kinase subfamily VII, RLCK VII)成员,直接磷酸化MAPKKK5的Ser近日,上海交通大学农业与生物学院薛红卫教授团队在New Phytologist发表了题为“Casein kinase 1 ImageTitle promote“Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish”。该研究利用斑马鱼突变体模拟了tuberculosisprotein kinase G impairs host immunity by acting as an unusualubiquitinating enzyme”。 刘翠华研究组的项目研究员汪原肌球蛋白受体激酶(tropomyosin receptor kinase,TRK主要包括TRKA、TRKB和TRKC三个亚型,分别由NTRK1、NTRK2和NTRKTitle: Protein Kinase Cand Wnt/Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma Author以Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response为题,在线发表在当肌肉遭受损伤时,肌肉中的酶也会释放到血中来,其中最常运用的检查就是肌氨酸激脢 (creatine kinase,CK)值的测定,在正常情况“Stripe rust effector Pst03724 modulates host immunity by inhibiting NAD kinase activation by a calmodulin”的研究论文。该研究TKI药物靶点的发展趋势及检测技术的更迭 酪氨酸激酶抑制剂(Tyrosine kinase inhibitors,TKI)为一类能抑制酪氨酸激酶活性的化合苏州大学王志新院士和吴嘉炜教授应邀分别作了题为“PAK家族蛋白激酶的自激活机制”和“Protein kinase and phosphatase文章模式图(图源自PNAS) 受体相互作用丝氨酸/苏氨酸蛋白激酶1 ( Receptor-Interacting Serine/ Threonine-Protein Kinase 1,并利用丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)抑制剂化合物库,筛选得到了Genistein(金转停)药物。该药物保罗•纳斯的主要学术贡献在于,利用遗传学和分子生物学的方法,发现并阐明了细胞周期蛋白依赖激酶(cyclin dependent kinase,2-Dilauroyl-sn-glycero-3-PE Aurora Kinase Inhibitor II Juglone CGP 20712 dihydrochloride Maltitol His-[D-2-ME-Trp]-Ala Maribavir来源:Pilgrim T, Vollenbroich R, Deckarm S, et al. Effect of Paroxetine-Mediated G-Protein Receptor Kinase 2 Inhibition vs2) Activation of JAK kinase and phosphorylation of thereceptor, 3) Recruitment and phosphorylation of STAT proteins by JAK, 4)BTK是一种酪氨酸激酶(Bruton's tyrosine kinase,简称BTK),在B细胞的发育和功能中起到重要作用。(Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells),于2012年2月17日在线发表。其信号的继续传递依赖于蛋白激酶A(protein kinase A,PKA) 在E.coli中dATP也参与转录调控。protein kinase activity via the peroxisome proliferator-activated receptor-co-activator-1brain-derived neurotrophic factor
KANSAI SEKAI国内电子乐大神VISUDY的 弛放 未来车库舞曲风格EP单曲KINASE哔哩哔哩bilibili丝裂原活化蛋白激酶MAPK(mitogenactivated protein kinase)动画哔哩哔哩bilibili都是新优品种!带营养杯组培吉塞拉矮化樱桃苗,错季种植新选择! 西瓜视频MAPK通路(1)哔哩哔哩bilibiliActivated Phosphoinositide 3Kinase Delta Syndrome哔哩哔哩bilibiliPI 3Kinase, Insulin Signaling and CancerProf. Lewis C. Cantley in ECAR2020哔哩哔哩bilibilikiss and make upSpecial KKiss Ya Neck
map kinase signaling全网资源fast facts: pyruvate kinase deficiency for patients and砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展protein kinase protocols全网资源预订protein kinase c protocols预订 protein kinase c in cancer signaling and therapyrole of glycogen synthase kinase预订protein kinase technologiesmap kinase signaling protocolskinase inhibitorskinase inhibitor drugs预订 protein kinase inhibitors as sensitizing agents预订 a molecular and cellular view of protein kinaseprotein kinase ck2 from structure to预订 a closer look at kinase inhibition预订 kinase drug discovery预订 atm kinaseglycogen synthase kinase 3carcinogenesis and protein kinase cphosphoinositide 3预订 protein kinase cprotein kinase ck2 cellular function in normal andphosphoinositide 3我国科学家揭示噬菌体逃逸细菌防御的新机制protein kinase inhibitors in research砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展预订kinase signaling networks【预订】leucineamp-activated protein kinaseactivated protein kinase signalling 9783038976622protein kinase预订proteinkinase inhibitors砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展【预订】The Cdk-Activating Kinase (Cak砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展我国科学家揭示噬菌体逃逸细菌防御的新机制protein kinase cactivating kinase砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展oncoprotein protein kinasenanoparticles with streptokinase as modifiedstreptokinase调控_是一种_kinasemyo蛋白;myo重组蛋白sugar kinase砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展砥砺深耕行致远,笃行不怠领芳华---"cns"研究新进展转化生长因子激酶1sugar kinaseprotein kinase ck2checkpoint kinasekcc4蛋白;kcc4重组蛋白serine/threonine/tyrosine protein kinase内毒素信号转导的途径及产生的原理反应px-866,pi3-kinase抑制剂creatine kinase isoenzymes: pathophy【预订】Is Aurora Kinase C agluconokinase activity assay kit
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本课题组在2017年报导激酶Checkpoint-kinase 1 (Chk1) 磷酸化OGT的S20位点,从而在胞质分离过程中上调OGT的丰度,进而导致胞...
如IPK1(Inositol-Pentakisphosphate 2-Kinase 1),IPK2 nostitol Polyphosphate Kinase 2 PI-PLC(...
中英文全称:酪氨酸激酶, 非受体, 1 tyrosine kinase, non-receptor, 1 分布:细胞质|膜 活性:核苷酸结合|非膜跨越蛋白酪氨酸 激酶|...
Fig.4 MAP kinase p38a is a multi-site tau kinase in vivo. 进一步分析表明,p38率𘤺依赖的作用机制下,小鼠体内神经元中的 tau...
可触发转胞吞的多功能载药纳米粒的构建及其体内抗PDAC作用 研究结果 02 FAK为英文单词Focal Adhesion Kinase的缩写,中文名称...
力-化协同治疗的HCPF水凝胶敷料可以缓解AD症状该工作证明了力学信号通路关键蛋白黏着斑激酶(Focal adhesion kinase, FAK)磷酸化...
而劳拉替尼则是目前仅有的获批上市的第三代间变性淋巴瘤激酶ALK(Anaplastic Lymphoma Kinase)抑制剂,适用于ALK阳性晚期非小...
以及治疗复发脑膜瘤患者的新的分子靶向Smoothened,AKT1和粘附斑激酶(focal adhesion kinase)的药物。
同时他们还发现了一种名为RIPK3(受体交互蛋白激酶3,Receptor-Interacting Protein Kinase 3)的特殊蛋白在调节MAIT细胞的数量...
同时他们还发现了一种名为RIPK3(受体交互蛋白激酶3,Receptor-Interacting Protein Kinase 3)的特殊蛋白在调节MAIT细胞的数量...
AMPK(AMP-activated protein kinase (AMPK))是一种丝氨酸/苏氨酸激酶,是真核细胞中一个重要的能量代谢感受器,在真核生物中...
在多西紫杉醇敏感细胞中,LINC01085可同时特异性结合TANK-binding kinase 1 (TBK1)和糖原合成酶激酶3(GSK3,抑制TBK1...
以及瑞典奥尔巴诺瓦大学等单位合作发现增强而非抑制谷氨酸激酶(glutamate kinase,GK)活性可杀死结核分枝杆菌(...
2018年,国际权威期刊《Cell Metabolism》期刊发表研究揭示,促成糖尿病的关键分子PKCrotein kinase C epsilon)来源不是...
该论文的标题是《乳腺肿瘤细胞重编程蛋白激酶抑制剂的鉴定》(Identification of protein kinase inhibitors to reprogram breast...
TM4SF1偶联盘状蛋白结构域受体酪氨酸激酶1 (discoidin domain receptor tyrosine kinase 1 , DDR1)在I型胶原刺激下激活了JAK2-...
图片来源:https://www.jci.org/articles/view/160929 MKD的发生是由编码甲羟戊酸激酶(mevalonate kinase)的基因突变所引起,该酶...
C轮融资的收益将投资于该公司的主要项目:LRRK2(leucine-rich repeat kinase 2)和TYK2 (tyrosine kinase 2)。LRRK2是一种与...
STING)的天然激动剂和STING结合后激活TANK结合激酶 1(TANK-binding kinase 1,TBK1),进而诱导干扰素nterferon ..
该研究首次揭示了糖原合成酶激酶3(glycogen synthase kinase 3, GSK3)家族基因在盐胁迫抑制大豆共生信号和根瘤形成过程中起...
我在哈佛做博士后的实验室里,有一位博士后是冯ⷨﺤ外孙,他自己在哈佛念研究生期间发现了一个新的重要的酶(PI3 kinase)...
我在哈佛做博士后的实验室里,有一位博士后是冯ⷨﺤ外孙,他自己在哈佛念研究生期间发现了一个新的重要的酶(PI3 kinase)...
Serine/Threonine Kinase 1 (SIK1) Through Phosphorylation 的研究论文 。生命科学技术学院2018级本科生穆俊羲、2020级硕士生...
资料来源:公司公告,格隆汇整理 JAK1是JAK(Janus kinase,一种非受体型酪氨酸蛋白激酶)家族的成员之一。JAK激酶家族的蛋白有...
研究成果以“GRK4在心肌梗死后心肌损伤中的作用(The Role of G Protein-Coupled Receptor Kinase 4 in Cardiomyocyte Injury...
利用c-Jun N-terminal protein kinase (JNK)和ImageTitle kinase(IKK)/NF-ImageTitle等分子探针来研究决定信号转导网络的可塑性(...
p38丝裂原活化蛋白激酶(Mitogen-activated protein kinase,MAPK)通路和表皮生长因子受体(Epidermal growth factor receptor,...
以前的研究显示,耶尔森菌效应蛋白ImageTitle靶向并抑制TAK1(transforming growth factor-activated kinase 1, 转化生长因子-..
ULK1复合物与ATG14-ImageTitle型磷脂酰肌醇-3激酶(class ImageTitle phosphoinositide 3-kinase,PIK3C3)复合物相互作用,...
2020年5月,美国医学院的研究人员在杂志上发表了一篇题为:A salt-induced kinase is required for the metabolic regulation of...
它是被报道的细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitors,CKI)家族的首个成员【7】。2000年,p21最早...
随后对这两种囊泡进行蛋白质组学分析,筛选到糖酵解通路的重要代谢酶PKM2(Pyruvate kinase M2)是肝癌细胞微囊泡中关键的传递...
FLT3-ITD)和FLT3酪氨酸激酶结构域(FLT3 tyrosine kinase domain, FLT3-TKD)有显著的抑制作用。FLT3-ITD突变影响约30%的...
于峰课题组及其合作者加州大学栾升教授在解析植物生长信号分子“接收器”上的重要进展——《A Receptor Kinase Complex...
定位于胞质的类受体激酶第七亚家族(receptor-like cytoplasmic kinase subfamily VII, RLCK VII)成员,直接磷酸化MAPKKK5的Ser...
近日,上海交通大学农业与生物学院薛红卫教授团队在New Phytologist发表了题为“Casein kinase 1 ImageTitle promote...
原肌球蛋白受体激酶(tropomyosin receptor kinase,TRK主要包括TRKA、TRKB和TRKC三个亚型,分别由NTRK1、NTRK2和NTRK...
当肌肉遭受损伤时,肌肉中的酶也会释放到血中来,其中最常运用的检查就是肌氨酸激脢 (creatine kinase,CK)值的测定,在正常情况...
TKI药物靶点的发展趋势及检测技术的更迭 酪氨酸激酶抑制剂(Tyrosine kinase inhibitors,TKI)为一类能抑制酪氨酸激酶活性的化合...
苏州大学王志新院士和吴嘉炜教授应邀分别作了题为“PAK家族蛋白激酶的自激活机制”和“Protein kinase and phosphatase...
文章模式图(图源自PNAS) 受体相互作用丝氨酸/苏氨酸蛋白激酶1 ( Receptor-Interacting Serine/ Threonine-Protein Kinase 1,...
并利用丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)抑制剂化合物库,筛选得到了Genistein(金转停)药物。该药物...
保罗•纳斯的主要学术贡献在于,利用遗传学和分子生物学的方法,发现并阐明了细胞周期蛋白依赖激酶(cyclin dependent kinase,...
BTK是一种酪氨酸激酶(Bruton's tyrosine kinase,简称BTK),在B细胞的发育和功能中起到重要作用。
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